Importance of ESR for the Prognosis of Disease Essay Example

Importance of ESR for the Prognosis of Disease Essay Example Importance of ESR for the Prognosis of Disease Essay Importance of ESR for the Prognosis of Disease Essay Thousandth Erythrocyte Sedimentation Rate (SEERS) Definition When a volume of blood is mixed with a specific amount of a suitable anticoagulant and is allowed to stand in a vertical position in a stand then the blood cells will settle down leaving the clear plasma above. This rate at which the sedimentation takes place in 1st hour is called Erythrocyte Sedimentation Rate (SEERS). Normal count Westerner Method Male mm in 1st hour WinWrite Method Tot 10 mm in 1st hour Female o to 20 O to 20 mm in 1st hour Importance of SEERS To see the prognosis of disease To assay the condition of some chronic inflammatory diseases, such as : I. Pulmonary tuberculosis it. Pulmonary embolism iii. Myocardial infraction v. Coronary thrombosis v. Rheumatic arthritis v. Carcinoma To see the therapeutic effects of drugs SEERS is high, raised or increased in Physiological conditions I. During menstruation it. During pregnancy iii. In high atmospheric pressure Pathological conditions I. Tuberculosis iii. Acute rheumatic fever iv. Malignancy v. Coronary thrombosis v. Other types of tissue necrosis vii. Hemorrhage viii. Pregnancy x. Toxic condition x. Anemia x. Chronic inflammation xii. Connective tissue or collagen disease, e. G. Systemic lupus erythrocytes (SSL) SEERS is low or decreased in I. In high altitude it. In dehydration iii. In defect of roulette formation I. Hamiltonians ii. Polytheism Vera iii. Stickle cell anemia Methods of SEERS estimation There are two methods of estimation of SEERS I. Westerner method lie. WinWrite method Materials required I. Westerner tube: It is a straight glass tube, 30 CM in length and 205 mm in diameter. It is calibrated in m. M. From O to 200. Epic -I ii The pictures show a rack holding WinWrite tubes, in which anticoagulants whole blood has Just been added (Time:O) in Picks I and Red blood cells have settled, leaving plasma at the top of the tube (Time: one hour) in Picks it. (Reading: 18 mm/ hour) Factors influence the SEERS The factors involved in the rate of fall of the RFC influence the SEERS. These are Factors which increase roulette formation and viscosity of plasma enhance SEERS: I. Increase plasma forefinger it. Increase plasma globulin iii. Increase plasma albumin v. Decrease plasma Hob con. V. Increase dilution of blood . Decrease number of RFC Technical and instrumental factors also influence SEERS: I. Position of SEERS tube: Properly vertical tube gives accurate reading. Any degree of inclination increase SEERS. It. Quantity of anticoagulant used: Excess potassium oxalate and sodium citrate increase and decrease the SEERS value respectively. Iii. Delay in the test: If the test is delayed after collection of blood, SEERS becomes high. Lb. Room determination: The length and diameter of the SEERS tube influence the value. Hence the value is more in WinWrite method than the Westerner method.